Reviewer
000-513-739
| Name: | Dr. S. MILTON PRABU |
| Designation: | Associate Professor |
| Department: | Zoology |
| Research Area: | Ecotoxicology and Phytothreapeutics |
| Organization: | University of Madras |
| Contact: | Contact Reviewer |
| Qualification: | PhD |
| About: | 2. Research area: Environmental Toxicology, Ethnomedicine, and Phyto-Pharmacotherapeutics The major area of my specialization is on the identification, separation and characterization of lead Phytochemicals from the Medicinal plants and to test them against heavy metals induced oxidative stress mediated multiple organ dysfunctions in rats. Medicinal plants represent the rich repository of natural products for the discovery of compounds with pharmacological properties like antoxidant, anti-hepatotoxic, antinephrotoxic, anti-carcinogenic, antibiotic, growth promoting or inhibiting, hemolytic analgesic, hypotensive and hypertensive agents. Most of the medicinal plants represent untapped resources of useful compounds or lead compounds for drugs against metal induced. Toxicological effects of heavy metals on terrestrial animals have been extensively investigated, while scarce research has been undertaken on the chelation therapy against the metal induced toxicity in rats. Most of the antioxidant Phytochemicals like polyphenols, terphenoids, carotenoids, coumarins, proantho cyanidins, stilbenes, lignans, catechins and sulphoraphanes showing marked curative properties against heavy metals induced toxicities. Hence, the plant based Phytochemicals represents a valuable source for pharmaco-therapuetics against oxidative stress mediated pathologies and may lead to the invention of new drugs/ chelators. • To delineate the heavy metals induced organ toxicity/cytotoxicity and their role in inducing oxidative stress, inflammation, necrosis and apoptosis in rodent model and cell lines • To identify lead antioxidant Phytochemicals from medicinal plants used in folk medicine. • To determine the biochemical changes induced by the heavy metals in rats at sublethal dose. • To pharmacologically characterize the protective effects of the lead phytochemical compounds against metal toxicity in rats. • To assess the anti-hepatoxoic, anti-nephrotoxic, cardioprotective, neuro |
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