Dietary polyphenols from plant
origins play a major role in the
human diet. They supply efficient
antioxidants that reduce or
prevent ROS production
depending on the concentration.
However, these polyphenols are
less bio-available in the body due
to various parameters, including
low intrinsic activity, poor
absorption, high metabolism,
inactivity of metabolic products, and/or rapid elimination. Quercetin and resveratrol are dietary polyphenols that are often found in the human
diet. However, they lag in bioavailability, which makes them less preferred nutraceuticals. This particular study is aimed at increasing the
bioavailability of quercetin and resveratrol through the nano vector system, niosomes. In this study, niosomes entrapped with Quercetin and
Resveratrol were produced in different concentrations of Span 60 and cholesterol using the thin film hydration method. The best suitable
composition, which provides maximum entrapment, was taken for further study. The niosomal formulation of quercetin and resveratrol was
evaluated using various methods like solubility and shape. The entrapment efficiency was determined to be 61.55%. The niosomes were then
characterized using a zeta sizer and a potential. The average particle size of niosomes was 194 diameter values in nanometers, and their zeta
potential was -20 mV, which indicated their good stability. The results of the in vitro drug release research, which was conducted using phosphate
buffer saline pH 7.4, were that 92.6% in 24 hours was significantly increased compared to quercetin and resveratrol release, 71.30%. The ex vivo
drug release was 94.5% after 24 hours, which was higher when compared to quercetin and resveratrol release of 75.74%. The results of this study
indicate that the niosomes significantly enhanced the bioavailability of quercetin and resveratrol.