Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

Lisa Kobayashi Frisk; Manish Verma; Faruk Bešlija; Chen-Hao P. Lin; Nishighanda Patil; Sumana Chetia; Jason W. Trobaugh; Joseph P. Culver; and Turgut Durduran

Comprehensive workflow and its validation for simulating diffuse speckle statistics for optical blood flow measurements

Author : Lisa Kobayashi Frisk, Manish Verma, Faruk Bešlija, Chen-Hao P. Lin, Nishighanda Patil, Sumana Chetia, Jason W. Trobaugh, Joseph P. Culver, and Turgut Durduran Journa Name: BIOMEDICAL OPTICS EXPRESS Country : USA Volume: 15 issue: 2 Year: 2024 Views : 292

Abstract:

Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast (?) to measure deep blood flow. In order to design practical systems, parameters such as signal-to-noise ratio (SNR) and the effects of limited sampling of statistical quantities, should be considered. To that end, we have developed a method for simulating speckle contrast signals including effects of detector noise. The method was validated experimentally, and the simulations were used to study the effects of physical and experimental parameters on the accuracy and precision of ?. These results revealed that systematic detector effects resulted in decreased accuracy and precision of ? in the regime of low detected signals. The method can provide guidelines for the design and usage of SCOS and/or SCOT instruments.