Ximenia americana, a plant widely distributed in tropical and subtropical regions, has been traditionally used for various medicinal purposes. This paper critically analyzes the bioactive compounds present in Ximenia americana and evaluates its potential anti-cancer properties. The review encompasses the phytochemical composition of Ximenia americana, focusing on compounds such as ximenynic acid, lupeol, and ?-sitosterol, among others, which have shown promising anti-cancer activities in preclinical studies. The aim of this study is to the Plant derived natural products had great promise for the discovery and development of new drugs. Preliminary screening tests are useful in the detection of different secondary metabolites in the plant crude extracts. Extraction with different solvents with increasing polarity influences the phytoconstituents present in the plants. Hence, in the present study different solvents (chloroform, ethyl acetate, methanol, ethanol and aqueous) were used for extraction. Furthermore, this paper discusses the mechanisms underlying the anti-cancer effects of these bioactive compounds, including their role in inducing apoptosis, inhibiting proliferation, and suppressing metastasis. The limitations and challenges in translating these preclinical findings into clinical applications are also addressed, highlighting the need for further research and clinical trials to fully explore the anti-cancer potential of Ximenia americana.