EVALUATION, OPTIMIZATION AND COMPARATIVE ANALYSIS OF DIFFERENT EXCIPIENTS FOR THE FORMULATION OF DAPSONE AND MOUTH DISSOLVING TABLETS
Author : Avinash Balasaheb Gangurde1 , Senthil Prabhu Rajendran2 , Pankaj M Pimpalshende3 , Mr.YogendraSahu4 , Nitin B Ghiware5 , Rajveer Bhaskar6*, Satendra kumar7 , Sharib Jamal8 Volume: 12 issue: S3 Year: 2023 Views : 231
Abstract:
Dapsone is used to treat leprosy and associated disorders because it is said to be active against the
Mycobacterium leprae. The goal of this study was to create mouth-dispersing Dapsone tablets using the direct
compression method and excipients such as sodium starch glycolate (SSG), crospovidone (CP), croscarmellose
sodium (CCS), and others that are directly compressible. The hardness, friability, weight variation, in vitro
dispersion time, wetting time, water absorption ratio, drug content uniformity, and in vitro dissolve rate of the
developed oral mouth dissolving of Dapsone were all assessed. Based on the findings of an in vitro drug release
research done in 0.1N HCL (PH 1.2), F- 6 was chosen as the formulation that was optimized among all the
others, and the in vitro release profiles were 99% accurate
Mycobacterium leprae. The goal of this study was to create mouth-dispersing Dapsone tablets using the direct
compression method and excipients such as sodium starch glycolate (SSG), crospovidone (CP), croscarmellose
sodium (CCS), and others that are directly compressible. The hardness, friability, weight variation, in vitro
dispersion time, wetting time, water absorption ratio, drug content uniformity, and in vitro dissolve rate of the
developed oral mouth dissolving of Dapsone were all assessed. Based on the findings of an in vitro drug release
research done in 0.1N HCL (PH 1.2), F- 6 was chosen as the formulation that was optimized among all the
others, and the in vitro release profiles were 99% accurate
