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Trehalose and its dihydrate: terahertz insights from solid to solution states

Author : Boyan Zhang, Zeyu Hou, Bingxin Yan, Yuhan Zhao, Bo Peng, Siyu Qian, Kai Li, Bo Su, and Cunlin Zhang Journa Name: BIOMEDICAL OPTICS EXPRESS Country : USA Volume: 15 issue: 5 Year: 2024 Views : 193
Abstract:
Carbohydrates are pivotal biomolecules in biochemistry; this study employs terahertz time-domain spectroscopy (THz-TDS) to investigate the spectral characteristics of trehalose and its hydrate across the 0.1 to 2.2 THz frequency range. Notable differences in spectra between the two compounds were observed. Density Functional Theory (DFT) simulations of the crystal structure were conducted to elucidate this phenomenon. The consistency between experimental results and simulations substantiates the reliability of the experimental findings. Additionally, the spectral characteristics of these carbohydrates in solution were examined using microfluidic chip technology. This approach facilitates a comprehensive comparison of their behaviors in both solid and solution states.

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