Towards a mini-endoscope design with spatially selective excitation and imaging

Loïc Tabourin; Frédéric Bretzner; and Tigran Galstian

Towards a mini-endoscope design with spatially selective excitation and imaging

Author : Loïc Tabourin, Frédéric Bretzner, and Tigran Galstian Journa Name: BIOMEDICAL OPTICS EXPRESS Country : USA Volume: 15 issue: 3 Year: 2024 Views : 374

Abstract:

We describe a mini-endoscope design that uses a new type of electrically tunable liquid crystal lens array enabling the dynamic increase of spatial resolution by adjusting the working distance in various zones of interest over a relatively large field of view (FoV) without mechanical movement. The characterization of the system is performed by using uniform fluorescent films, fluorescent micro spheres and a tissue sample expressing the fluorescent calcium indicator GCaMP6s. Lateral resolution of up to 2 µm over the FoV between 300 µm - 400 µm is experimentally demonstrated.