Abstract: The study attempts to investigate the effect of Agency Cost (AGCOST), Good Corporate Governance (GCG), Capital Adequacy Ratio (CAR), Loan Deposit Ratio (LDR), Non Performing Loan (NPL), interest rate (BI7DAY) and foreign exchange rate (KURS) to bank profitability measured by Return on Assets (ROA). The sample consists of 29 banks listed in Otoritas Jasa Keuangan (OJK) during 2012 – 2021. Sampling method was census. Data analysis method was panel data regression method. The novelty of the research is using the ratio of board of director’s and commissioner’s remuneration to total salary as the proxy of AGCOST. GCG was proxied by percentage of institutional ownership. Result shows that NPL, AGCOST and GCG have a significant negative effect to ROA; CAR and BI7DAY have a significant positive effect to ROA; LDR and KURS have a insignificant effect to ROA. Conclusion of the study: escalating the board’s remuneration and institutional ownership will decrease ROA.