SLAM medical imaging enabled by a pre-chirp and gain jointly managed Yb-fiber laser

Yuting Xing; Runzhi Chen; Lihao Zhang; Yaobing Chen; Shu Zhang; Xincai Diao; Yang Liu; Yishi Shi; Zhiyi Wei; and Guoqing Chang

SLAM medical imaging enabled by a pre-chirp and gain jointly managed Yb-fiber laser

Author : Yuting Xing, Runzhi Chen, Lihao Zhang, Yaobing Chen, Shu Zhang, Xincai Diao, Yang Liu, Yishi Shi, Zhiyi Wei, and Guoqing Chang Journa Name: BIOMEDICAL OPTICS EXPRESS Country : USA Volume: 15 issue: 2 Year: 2024 Views : 257

Abstract:

We demonstrate a pre-chirp and gain jointly managed Yb-fiber laser that drives simultaneous label-free autofluorescence-multiharmonic (SLAM) medical imaging. We show that a gain managed Yb-fiber amplifier produces high-quality compressed pulses when the seeding pulses exhibit proper negative pre-chirp. The resulting laser source can generate 43-MHz, 34-fs pulses centered at 1110?nm with more than 90-nJ energy. We apply this ultrafast source to SLAM imaging of cellular and extracellular components in various human tissues of intestinal adenocarcinoma, lung adenocarcinoma, and liver.