This study investigates the design and implementation of a Smart Healthcare System (SHS) integrated into a Disaster Management and Mitigation System (DMMS), using Lusaka, Zambia as a case study. The increasing frequency of disasters such as cholera outbreaks, floods, and the COVID-19 pandemic have demonstrated the limitations of conventional healthcare systems in responding effectively. The SHS aims to enhance real-time data collection, health monitoring, early warning systems, and coordinated emergency response. Through qualitative methodology, data were collected from healthcare professionals, ICT experts, and disaster management personnel. Findings show that a well-integrated SHS can significantly improve response time, resource allocation, and resilience during disasters. The research contributes to local and continental knowledge on digital health innovations in disaster-prone regions.