Contemporary organisations operate in environments characterised by technological change, market uncertainty, complex customer expectations and increasing competition. These conditions require organisations to move beyond isolated expertise and develop mechanisms through which knowledge can be exchanged, interpreted and recombined across professional and disciplinary boundaries. Cognitive cross-pollination describes this process of bringing together different perspectives, experiences, conceptual frameworks and specialised knowledge to generate new insights and innovative solutions. This paper examines the relationship between cognitive cross-pollination, knowledge exchange, interdisciplinary thinking and organisational innovation. It also identifies the organisational conditions that facilitate cross-disciplinary learning and proposes a conceptual framework explaining how diverse knowledge resources can be transformed into innovative outcomes. A conceptual, literature-based approach was adopted. Foundational theories and relevant scholarly publications on knowledge creation, organisational learning, absorptive capacity, social networks, team diversity, creativity, psychological safety and open innovation were critically reviewed and synthesised. The literature was organised thematically to identify common mechanisms, enabling conditions, barriers and theoretical relationships. The synthesis suggests that cognitive cross-pollination depends not merely on the availability of diverse knowledge but also on the organisation’s capacity to exchange, interpret, integrate and apply that knowledge. Interdisciplinary interaction can expand the range of ideas available for problem-solving, while psychological safety, inclusive leadership, shared goals and effective knowledge-management practices can facilitate the integration of different perspectives. However, disciplinary silos, communication barriers, status differences, knowledge-protection concerns and excessive coordination can weaken these benefits. The proposed framework provides a basis for future empirical investigation across organisational settings.