Symptomatic relief from ailments like peptic ulcers, acid reflux, and heartburn. A cornerstone of gastrointestinal care for many years, offering symptomatic relief from conditions like heartburn, acid reflux. This review study provides a thorough overview of the safety profile, efficacy, and mechanisms of action. It looks at the many antacid classes, including those based on aluminum, magnesium, and calcium, and outlines the benefits and drawbacks of each, Additionally, it talks about the potential side effects and drug interactions associated with antacid usage, emphasizing the importance of proper dosing and supervision. Antacids are medications that neutralize gastric acids to treat indigestion and heartburn. Antacids that are prescribed to oneself are a common drug. It is composed of various mixtures of aluminum, magnesium, and calcium salts. Antacids fall into two main categories: absorbable and non-absorbable. Fever adverse effects and additional benefits are associated with non-absorbable antacids. Each antacid has a different active ingredient that has a different effect on stomach acid. This narrative overview describes the mechanisms, properties, and disadvantages of the many antacid ingredients as well as the tools and resources for studying antacid compositions\' capacity to buffer acid.