In response to the growing global emphasis on sustainability, the packaging and printing ecosystem has witnessed a remarkable shift towards more eco-conscious practices. This comprehensive review paper, titled “A Review on Sustainable Packaging and Printing Ecosystem: A Study on Design, Materials, and Economical and Operational Aspects,” provides a thorough examination of the multifaceted dimensions shaping the sustainable evolution of packaging and printing industries. At its core, this review paper delves into the intricate relationship between design, materials, and the economic and operational aspects of these industries. It draws upon insights from selected studies to offer a holistic understanding of the key components driving sustainability in packaging and printing. One pivotal aspect explored in this review is the concept of “Design for Sustainability.” It illuminates innovative design strategies that prioritise reducing environmental impact, minimizing waste, and embracing the principles of a circular economy. Furthermore, the paper underscores the importance of user-friendly design approaches that align with eco-conscious practices. Materials play a central role in the pursuit of sustainability, and this review scrutinizes the adoption of sustainable alternatives. It sheds light on materials such as biodegradable polymers, cellulose nanofibers, and natural fibers, examining their environmental benefits and challenges in detail. Economic considerations are another critical facet discussed within the paper. It delves into the economic implications of sustainable packaging and printing, addressing issues of cost-effectiveness, resource conservation, and the competitive advantages that sustainability can confer in the market. Operational efficiency is also a key focus of this review, offering insights into how sustainable practices impact the day-to-day operations of packaging and printing industries. This includes discussions on efficiency gains, reduced energy consumption, and effective waste management. Technological advancements are highlighted as well, with an emphasis on cutting-edge innovations such as smart packaging and 3D printing. These technologies are shown to contribute significantly to sustainability efforts by enhancing product monitoring, traceability, and the development of intelligent materials. In essence, this review paper presents a comprehensive and cohesive perspective on the journey towards sustainability within the packaging and printing ecosystem. By synthesizing insights from diverse research areas, it aims to provide a roadmap for industry stakeholders to navigate the evolving landscape of environmentally responsible and economically viable solutions.