Among anorectal disorders, Parikartika is a common and painful ailment that resembles an anorectal fissure. A patient with Parikartika experiences excruciating agony during and after defecation, which last for a while and is sometimes accompanied by mild to moderate bleeding. Modern lifestyle changes, including sedentary work schedules, elevated stress levels, and unhealthy eating and sleeping patterns, are causing a steady rise in a number of lifestyle illnesses. Aim and Objective: The aim is comparison between Ayurvedic therapy, lateral sphincterotomy and lord's dilatation assess in the management of Parikartika (Acute fissure?in?ano). Materials and Methods: A total of 60 patients of acute fissure?in?ano were selected and randomly allocated into three groups (20 in each group). In Group A (n = 20), Ayurvedic remedies were given. Group B (n = 20), were treated with Lord’s dilatation & Group C (n = 20), were treated with Lateral Internal Sphincterotomy. The fissure was treated for four weeks, and the results were evaluated using the graded system that was chosen. Results: The Study showed that Group A remedies were more effective than Group B & C in treating Parikartika. In this study, group-A showed maximum improvement in all assessment criteria as compare to other groups. Conclusion: The outcome revealed a better therapeutic efficacy of Ayurvedic remedies in the whole symptom of Parikartika without any adverse effects.